Mechanics in medicine.

نویسنده

  • H R PERKINS
چکیده

Over decades, the Theoretical and Applied Mechanics (TAM) community has developed sophisticated approaches for analyzing the behavior of complex engineering systems. Most of these approaches have targeted systems in the transportation, materials, defense, and energy industries. Applying and further developing engineering approaches for understanding, predicting, and modulating the response of complicated biomedical processes not only holds great promise in meeting societal needs but also poses serious challenges. This report aims to identify the most pressing challenges in Biological Sciences and Medicine that can be tackled within the broad field of Mechanics. This echoes and complements a number of national and international initiatives aiming at fostering interdisciplinary biomedical research. This report also comments on cultural/educational challenges. Specifically, the report focuses on three major thrusts in which we believe mechanics has and will continue to have a substantial impact: i) Rationally engineering injectable nano/microdevices for imaging and therapy of disease. Within this context, we discuss nanoparticle carrier design, vascular transport and adhesion, endocytosis, and tumor growth in response to therapy, as well as uncertainty quantification techniques to better connect models and experiments. ii) Design of biomedical devices including point-of-care diagnostic systems, model organ and multi-organ microdevices, and pulsatile ventricular assistant devices. iii) Mechanics of cellular processes, including mechanosensing and mechanotransduction, improved characterization of cellular constitutive behavior, and microfluidic systems for single cell studies.

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عنوان ژورنال:
  • Journal of the Medical Association of Georgia

دوره 49  شماره 

صفحات  -

تاریخ انتشار 1960